Case Study: The Royal Marsden NHS Foundation Trust launches in-house HRD testing with SOPHiA GENETICS GIInger™

The Royal Marsden NHS Foundation Trust launches in-house HRD testing in under 21 days with SOPHiA GENETICS

The Royal Marsden NHS Foundation Trust needed to establish an in-house method for Homologous Recombination Deficiency (HRD) testing for ovarian cancer patients to avoid sending samples abroad. Their challenge was to find a bioinformatics solution that could integrate with their existing NGS chemistry and workflow to provide genomic instability scores and enable patient access to targeted therapies.

SOPHiA GENETICS implemented its GIInger Genomic Integrity Solution, which was integrated with the trust's in-house BRCA testing. The solution achieved 100% concordance with an orthogonal method. By utilizing SOPHiA GENETICS' platform, the trust successfully launched its service, processing 106 samples internally with an average turnaround time of under 21 days, significantly improving operational efficiency.

The Royal Marsden NHS Foundation Trust