Case Study: Guardant Health achieves zero-downtime Kubernetes management with Rafay

Guardant Health Chooses Rafay for Kubernetes Management for Mission-Critical Analytics

Guardant Health, a precision oncology company, relied on a high-performance computing environment to analyze biological samples and deliver time-sensitive results to doctors and patients. Its DIY open-source Kubernetes setup on bare metal was difficult to maintain, prone to downtime, slow to deploy, and hard to secure, while the company needed a reliable, enterprise-grade Kubernetes platform for mission-critical analytics. Guardant Health turned to Rafay and its Kubernetes Management Cloud (KMC) to modernize its orchestration layer.

With Rafay, Guardant Health deployed a zero-downtime, zero-trust Kubernetes management infrastructure supporting both cloud and on-premises environments. The solution added SSO, RBAC, automated auditing, and standardized cluster blueprints, enabling rapid application deployments—sometimes a dozen or more times per day and tested to thousands an hour—while reducing operational overhead and improving portability. As a result, Guardant Health reported no reliability issues and far fewer infrastructure alerts, allowing the team to focus on cancer research and patient outcomes rather than Kubernetes maintenance.

Guardant Health

William Baird

Manager of Infrastructure Engineering