Case Study: Institut Pasteur gains instant insight into immunology data with Qlucore Omics Explorer

Institut Pasteur accelerates immunology analysis with Qlucore for 450-gene studies

The Institut Pasteur, a leading research institute, sought to better understand the role of Th17 cells in chronic immune-mediated inflammatory diseases like Ankylosing Spondylitis. Dr. Elisabetta Bianchi's team needed a powerful tool to analyze large-scale gene expression data, having previously relied on limited methods like Excel for smaller datasets. They turned to Qlucore and its Omics Explorer product to gain a comprehensive overview of their complex immunology data.

Using Qlucore Omics Explorer for principal component analysis (PCA) and heatmap visualizations, the team efficiently analyzed a panel of 450 immune-related genes. The Qlucore solution enabled them to identify a surprising phenotypic switch, discovering that cells unable to express the RORγt transcription factor defaulted to a Th1 cell phenotype. This crucial insight, which would have been missed with their previous methods, was vital for their research published in Nature Communications and guides their future work with even larger RNA sequencing datasets.

Institut Pasteur