Case Study: York University advances epilepsy research with Molecular Devices Axon patch-clamp solutions

York University reduces 50/60 Hz noise in zebrafish epilepsy research with Molecular Devices

York University's Zoidl lab faced the challenge of investigating the role of pannexin channels in epilepsy using an in vivo zebrafish model, a process complicated by significant line-frequency noise interference in their electrophysiology recordings. This interference obscured the biological signals they needed to study, hindering their research into the neural circuitry of their genetically modified zebrafish lines.

Molecular Devices provided a solution with their Axon Digidata 1550B Low-Noise Data Acquisition System plus HumSilencer, which eliminated the 50/60Hz line-frequency noise to reveal clear biological signals. Using this equipment from Molecular Devices, the team successfully established their electrophysiological setup, determined the neuroprotective properties of Panx1, and uncovered a way to repurpose an FDA-approved drug to reduce seizure activity, leading to a significant publication on their findings.

York University