Case Study: Illumina Lab Services achieves 100,000-genome sequencing scale with Semaphore Solutions

LIMS Customization Key to High-throughput Whole Genome Sequencing

Illumina Lab Services (ILS) worked with Semaphore Solutions to scale its laboratory informatics for population-scale genomics. As sequencing demand grew and the team moved toward support for platforms like HiSeqX and NovaSeq, ILS needed a highly automated Laboratory Information Management System (LIMS) with complex workflow logic, strong traceability, and clinical-grade validation.

Semaphore Solutions customized and extended Clarity LIMS, integrating automation, workflow branching, and bioinformatics connections to BaseSpace Sequence Hub while supporting validation and training for the ILS team. The result was a production-ready, high-throughput system that helped ILS reach the milestone of 100,000 genomes sequenced by December 2018 and expand its sequencing capacity for cancer and rare disease workflows.

Illumina Lab Services