Case Study: Signant Health achieves rapid global eCOA rollout and 30,000 weekly micropayments to boost participant engagement with Greenphire

Greenphire Collaborates with eCOA Solution Provider for High-Profile Vaccine Study

Signant Health partnered with Greenphire and a top US pharmaceutical sponsor to deliver eCOA for a Phase II/III vaccine trial spanning 44,000+ healthy volunteers, 150+ sites and 5+ countries. The key challenges were keeping participants engaged and compliant for up to two years of symptom reporting, meeting an accelerated five‑week deployment timeline, and scaling without adding site burden.

Signant delivered SmartSignals eCOA apps (BYOD plus 8,000 provisioned devices) and a secure daily data integration with Greenphire to transmit completion and payment milestones; Greenphire issued ~30,000 weekly ClinCard micropayments in the US. The solution was deployed on time, produced regulatory‑quality data that supported EUA and later full FDA authorization, generated positive participant feedback, and reduced workload at sites while improving retention.

Signant Health