Case Study: Novartis achieves automated, days‑instead‑of‑weeks mass‑spectrometry analysis of therapeutic oligonucleotide biotransformations with Genedata Expressionist

Novartis - Customer Case Study

Novartis’ ADME laboratory in Basel faced a growing bottleneck analyzing high-resolution UPLC–MS data for oligonucleotide therapeutics: complex sample matrices, many possible metabolites from nucleotide clipping and modifications, and labor‑intensive, error‑prone manual workflows made comprehensive metabolic profiling slow and impracticable. To address this, Novartis partnered with Genedata and deployed the Genedata Expressionist platform.

Genedata implemented a server‑based, workflow‑driven solution (Genedata Expressionist) that auto‑generates sample‑specific metabolite libraries, runs sequential MS searches with rule‑based filtering, and produces customizable, submission‑ready reports. The automated pipeline cut analysis time from weeks to 1–2 days, reduced the volume of results requiring expert review, minimized manual errors, and provided deeper metabolic insights while enabling scalable, faster decision‑making.

Novartis

Katharina Root

Scientist