Case Study: Amicus Therapeutics achieves weeks-to-hours MS glycan characterization with Genedata Expressionist

Amicus Therapeutics - Customer Case Study

Amicus Therapeutics, a biotechnology company developing treatments for rare metabolic diseases such as Pompe disease, faced a major bottleneck in characterizing highly heterogeneous and phosphorylated glycosylation on recombinant alpha‑glucosidase (GAA). Working with Genedata and using Genedata Expressionist, they struggled with time‑consuming, expert‑driven MS data annotation that took weeks per sample, complex PTM analysis, and siloed data that limited collaboration and knowledge reuse.

Genedata implemented Genedata Expressionist with tailored MS processing workflows, custom glycan libraries, intuitive ion‑map/3D visualizations, and a centralized enterprise platform to consolidate data and metadata. The solution reduced sample characterization time from weeks to hours, dramatically increased analytical throughput, improved candidate selection quality, and converted dispersed MS data into a reusable corporate knowledge base.

Amicus Therapeutics

Nastry Brignol

Senior Scientist