Case Study: Top-20 Pharmaceutical Company achieves 5× faster peptide optimization with Cradle

Top-20 Pharmaceutical Company achieves ≥50% peptide constraint compliance with Cradle in one round

The customer, a top-20 pharmaceutical company, faced a critical challenge in optimizing three late-stage therapeutic peptide programs. After multiple failed rounds of traditional methods, they were unable to develop candidates that simultaneously met the tight, non-negotiable constraints for potency, specificity, expression, and thermostability, bringing the programs to a near dead end.

Cradle implemented its optimization solution, generating 96 candidates per program in a single round. The result was a dramatic success, with over 50% of Cradle's candidates meeting all constraints—a rate significantly higher than historical efforts. This enabled the partner to advance multiple peptides to the next stage, achieving a 5x acceleration in their development timeline and rescuing all three stalled programs.