Case Study: Mount Sinai achieves rapid, secure genomic discovery for hereditary breast and ovarian cancer with Amazon Web Services

Mount Sinai - Customer Case Study

The Icahn School of Medicine at Mount Sinai, a leader in biomedical research and clinical care, set out to find the genetic causes of breast and ovarian cancers beyond known BRCA1/2 mutations using more than 2,000 tumor and germline sequences from The Cancer Genome Atlas—a dataset exceeding 100 TB. The scale, sensitivity, and need for secure, collaborative reanalysis created a major computing, storage, and data‑security challenge for the research team.

Mount Sinai partnered with Station X to run the GenePool genomics platform on Amazon Web Services, giving the team elastic compute, centralized secure storage, strict access controls, and real‑time analytics. The solution enabled rapid, compliant mining and cross‑referencing of thousands of patient records, produced novel candidate genes and enriched marker lists for hereditary breast and ovarian cancer, and made large‑scale collaborative analysis feasible where it had not been before.

Mount Sinai

Sandeep Sanga

Vice President of Products, Station X