Case Study: Top-20 Pharmaceutical Company achieves 20% higher enrollment and 21% fewer protocol deviations with Advarra

Meeting Multiple Challenges for a Uniquely Challenging Trial

Top-20 Pharmaceutical Company was running a phase 3 breast cancer study across 16 countries with 188 sites and just 250 patients to enroll in a 12-month window. Facing a very small eligible patient pool (5–10%), heavy competition from other trials, and the need for tight protocol compliance, the sponsor’s CRO engaged Longboat — with support from Advarra — to deliver a custom online site portal to boost site engagement and streamline study operations.

Advarra (in collaboration with Longboat) implemented a tailored portal featuring study-specific trainings, ready access to study systems and an eLibrary, a patient scheduling/visit manager, and newsletters/video messages to keep sites engaged. Sites using the portal made fewer mistakes and queries and had measurable gains: the most active sites achieved 20% more enrollment, 50% fewer screen failures, 2x more patients enrolled per site, and portal users showed 21% fewer protocol deviations, demonstrating Advarra’s positive impact on study performance.